Active A · Cell Turnover / RetinoidsTier 2 Viscosity

Bakuchiol

Ideal Formulation pH: 5 – 6.5
Preferred Routine Slot: AM/PM
Pregnancy Safety: CAUTION LOW DOSE
Typical Clinical Dose: 0.5% – 1.0%
Active B · Cell Turnover / RetinoidsTier 2 Viscosity

Retinol

Ideal Formulation pH: 5.5 – 6.5
Preferred Routine Slot: PM
Pregnancy Safety: DEFER IN PREGNANCY
Typical Clinical Dose: 0.1% – 1.0%
🧪Viscosity & pH Application Order

How to Layer These Actives in Your Routine

Step 01Viscosity Tier 2

Bakuchiol

Apply first to clean, dry skin. Operates at pH 5–6.5.

⏱️Alternate Evenings

Avoid layering in the same evening session.

Step 02Viscosity Tier 2

Retinol

Layer over the initial active. Operates at pH 5.5–6.5.

Biochemical Mechanism & Pharmacology

Both Bakuchiol and Retinol belong to the Cell Turnover / Retinoids family and target identical cutaneous receptors and keratolytic pathways. Layering two separate formulas from this family multiplies barrier irritation and peeling without improving receptor saturation or therapeutic results.

Cutaneous pH Stability Note:

Select one primary formulation from this active class per routine session. Never stack high-strength exfoliants or multiple retinoids.

Recommended 7-Day Routine Blueprint

Morning (AM) RoutineEvening (Night A)Evening (Night B)
✓Gentle Cleanser
✓Hydrating Serum
✓Broad-Spectrum SPF 50+
•Use either Bakuchiol OR Retinol
•Rest Night: Barrier Creams & Ceramides

Obstetric & Pregnancy Safety Summary

View Full Pregnancy Directory →

Bakuchiol is classified as CAUTION LOW DOSE during pregnancy, while Retinol is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.

Clinical Studies & Pharmacological Citations