Active A · Anti-Erythema & ExtremolytesTier 2 Viscosity

Centella Asiatica & Madecassoside

Ideal Formulation pH: 5 – 6.5
Preferred Routine Slot: AM/PM
Pregnancy Safety: PERMITTED
Typical Clinical Dose: 0.5% – 2.0% titrated extract
Active B · Direct Acids & ExfoliantsTier 1 Viscosity

Salicylic Acid (BHA)

Ideal Formulation pH: 3 – 4
Preferred Routine Slot: AM/PM
Pregnancy Safety: CAUTION LOW DOSE
Typical Clinical Dose: 0.5% – 2.0%
🧪Viscosity & pH Application Order

How to Layer These Actives in Your Routine

Step 01Viscosity Tier 1

Salicylic Acid (BHA)

Apply first to clean, dry skin. Operates at pH 3–4.

⏱️Wait 2 Minutes

Allows cutaneous acid mantle to equilibrate before the next step.

Step 02Viscosity Tier 2

Centella Asiatica & Madecassoside

Layer over the initial active. Operates at pH 5–6.5.

Biochemical Mechanism & Pharmacology

Centella Asiatica & Madecassoside provides vital physiological lipids and humectants that reinforce the stratum corneum lipid matrix, preventing trans-epidermal water loss (TEWL) and buffering against irritation from Salicylic Acid (BHA) without attenuating its therapeutic cellular benefits.

Cutaneous pH Stability Note:

Apply the lower viscosity product first, or buffer by applying Centella Asiatica & Madecassoside prior to Salicylic Acid (BHA) for sensitive skin (the sandwich method).

Recommended 7-Day Routine Blueprint

Morning (AM) RoutineEvening (Night A)Evening (Night B)
✓Gentle Cleanser
✓Centella Asiatica & Madecassoside
✓Broad-Spectrum SPF 50+
•Salicylic Acid (BHA)
•Centella Asiatica & Madecassoside
•Barrier Seal
•Salicylic Acid (BHA)
•Centella Asiatica & Madecassoside
•Barrier Seal

Obstetric & Pregnancy Safety Summary

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Centella Asiatica & Madecassoside is classified as PERMITTED during pregnancy, while Salicylic Acid (BHA) is classified as CAUTION LOW DOSE under clinical guidelines. Always cross-reference with your physician if expecting.

Clinical Studies & Pharmacological Citations