Centella Asiatica & Madecassoside
Tretinoin (All-Trans Retinoic Acid)
How to Layer These Actives in Your Routine
Centella Asiatica & Madecassoside
Apply first to clean, dry skin. Operates at pH 5–6.5.
Allows cutaneous acid mantle to equilibrate before the next step.
Tretinoin (All-Trans Retinoic Acid)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Centella Asiatica & Madecassoside provides vital physiological lipids and humectants that reinforce the stratum corneum lipid matrix, preventing trans-epidermal water loss (TEWL) and buffering against irritation from Tretinoin (All-Trans Retinoic Acid) without attenuating its therapeutic cellular benefits.
Apply the lower viscosity product first, or buffer by applying Centella Asiatica & Madecassoside prior to Tretinoin (All-Trans Retinoic Acid) for sensitive skin (the sandwich method).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Centella Asiatica & Madecassoside ✓Broad-Spectrum SPF 50+ | •Centella Asiatica & Madecassoside •Tretinoin (All-Trans Retinoic Acid) •Barrier Seal | •Centella Asiatica & Madecassoside •Tretinoin (All-Trans Retinoic Acid) •Barrier Seal |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Centella Asiatica & Madecassoside is classified as PERMITTED during pregnancy, while Tretinoin (All-Trans Retinoic Acid) is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.