Copper Tripeptide-1 (GHK-Cu)
Salicylic Acid (BHA)
How to Layer These Actives in Your Routine
Salicylic Acid (BHA)
Apply first to clean, dry skin. Operates at pH 3–4.
Avoid layering in the same evening session.
Copper Tripeptide-1 (GHK-Cu)
Layer over the initial active. Operates at pH 5.5–7.
Biochemical Mechanism & Pharmacology
The tripeptide-copper complex GHK-Cu relies on a specific coordinate bond with copper(II) ions. Exposure to low-pH proton-rich solutions (< pH 4.0) from Salicylic Acid (BHA) destabilizes this chelation bond, causing copper release. Free copper ions trigger rapid oxidation of ascorbic acid or active hydrolysis of peptide chains, rendering both therapeutically inert.
Salicylic Acid (BHA) requires acidic pH (3–4), while Copper Tripeptide-1 is stable only between pH 5.5–7.0. Dedicate one to Morning and the other to Evening.
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Salicylic Acid (BHA) ✓Moisturizer ✓Broad-Spectrum SPF 50+ | •Copper Tripeptide-1 (GHK-Cu) •Barrier Cream | •Copper Tripeptide-1 (GHK-Cu) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Copper Tripeptide-1 (GHK-Cu) is classified as PERMITTED during pregnancy, while Salicylic Acid (BHA) is classified as CAUTION LOW DOSE under clinical guidelines. Always cross-reference with your physician if expecting.