Copper Tripeptide-1 (GHK-Cu)
Tretinoin (All-Trans Retinoic Acid)
How to Layer These Actives in Your Routine
Copper Tripeptide-1 (GHK-Cu)
Apply first to clean, dry skin. Operates at pH 5.5–7.
Allows cutaneous acid mantle to equilibrate before the next step.
Tretinoin (All-Trans Retinoic Acid)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Copper Tripeptide-1 (GHK-Cu) and Tretinoin (All-Trans Retinoic Acid) operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Copper Tripeptide-1 (GHK-Cu) (pH 5.5–7, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Tretinoin (All-Trans Retinoic Acid).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Copper Tripeptide-1 (GHK-Cu) ✓Broad-Spectrum SPF 50+ | •Copper Tripeptide-1 (GHK-Cu) •Tretinoin (All-Trans Retinoic Acid) •Barrier Cream | •Copper Tripeptide-1 (GHK-Cu) •Tretinoin (All-Trans Retinoic Acid) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Copper Tripeptide-1 (GHK-Cu) is classified as PERMITTED during pregnancy, while Tretinoin (All-Trans Retinoic Acid) is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.