Hyaluronic Acid & Multi-Weight Polyols
Polyglutamic Acid (PGA)
How to Layer These Actives in Your Routine
Hyaluronic Acid & Multi-Weight Polyols
Apply first to clean, dry skin. Operates at pH 5–7.
Allows cutaneous acid mantle to equilibrate before the next step.
Polyglutamic Acid (PGA)
Layer over the initial active. Operates at pH 5.5–6.5.
Biochemical Mechanism & Pharmacology
Hyaluronic Acid & Multi-Weight Polyols and Polyglutamic Acid (PGA) operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Hyaluronic Acid & Multi-Weight Polyols (pH 5–7, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Polyglutamic Acid (PGA).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Hyaluronic Acid & Multi-Weight Polyols ✓Broad-Spectrum SPF 50+ | •Hyaluronic Acid & Multi-Weight Polyols •Polyglutamic Acid (PGA) •Barrier Cream | •Hyaluronic Acid & Multi-Weight Polyols •Polyglutamic Acid (PGA) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Hyaluronic Acid & Multi-Weight Polyols is classified as PERMITTED during pregnancy, while Polyglutamic Acid (PGA) is classified as PERMITTED under clinical guidelines. Always cross-reference with your physician if expecting.