Panthenol (Provitamin B5)
Tretinoin (All-Trans Retinoic Acid)
How to Layer These Actives in Your Routine
Panthenol (Provitamin B5)
Apply first to clean, dry skin. Operates at pH 5–6.5.
Allows cutaneous acid mantle to equilibrate before the next step.
Tretinoin (All-Trans Retinoic Acid)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Panthenol (Provitamin B5) provides vital physiological lipids and humectants that reinforce the stratum corneum lipid matrix, preventing trans-epidermal water loss (TEWL) and buffering against irritation from Tretinoin (All-Trans Retinoic Acid) without attenuating its therapeutic cellular benefits.
Apply the lower viscosity product first, or buffer by applying Panthenol (Provitamin B5) prior to Tretinoin (All-Trans Retinoic Acid) for sensitive skin (the sandwich method).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Panthenol (Provitamin B5) ✓Broad-Spectrum SPF 50+ | •Panthenol (Provitamin B5) •Tretinoin (All-Trans Retinoic Acid) •Barrier Seal | •Panthenol (Provitamin B5) •Tretinoin (All-Trans Retinoic Acid) •Barrier Seal |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Panthenol (Provitamin B5) is classified as PERMITTED during pregnancy, while Tretinoin (All-Trans Retinoic Acid) is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.