Signal Peptides (Matrixyl 3000)
Retinol
How to Layer These Actives in Your Routine
Signal Peptides (Matrixyl 3000)
Apply first to clean, dry skin. Operates at pH 5–7.
Allows cutaneous acid mantle to equilibrate before the next step.
Retinol
Layer over the initial active. Operates at pH 5.5–6.5.
Biochemical Mechanism & Pharmacology
Signal Peptides (Matrixyl 3000) and Retinol operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Signal Peptides (Matrixyl 3000) (pH 5–7, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Retinol.
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Signal Peptides (Matrixyl 3000) ✓Broad-Spectrum SPF 50+ | •Signal Peptides (Matrixyl 3000) •Retinol •Barrier Cream | •Signal Peptides (Matrixyl 3000) •Retinol •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Signal Peptides (Matrixyl 3000) is classified as PERMITTED during pregnancy, while Retinol is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.