← Back to Ingredients Directory
Barrier Cofactors & BrightenersRecommended: PM Slot
Hydroquinone (2%–4%)
Clinical Overview
The historical gold-standard prescription tyrosinase competitor that exerts selective cytotoxicity on active melanocytes.
Epidermal & Cutaneous Mechanism
Competes with tyrosine for tyrosinase binding and degrades intracellular melanosomes; requires strict medical cyclical supervision to prevent exogenous ochronosis.
Addresses Skin Concerns
Severe recalcitrant melasmaDeep post-inflammatory hyperpigmentation
Recognized INCI Names on Packaging Labels
Hydroquinone
Compatible Synergies
- ✓Tretinoin (Kligman formula)
- ✓Mild Hydrocortisone
Separate or Alternate
- ⚠️Benzoyl Peroxide (causes temporary dark staining)
- ⚠️Hydrogen peroxide