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Osmolytes & HumectantsRecommended: AM/PM Slot

Urea (5%–10%)

Clinical Overview

An endogenous natural moisturizing factor component that dissolves keratolytic scaling while drawing water into corneum cells.

Epidermal & Cutaneous Mechanism

Disrupts hydrogen bonds in dense keratin aggregates at 5%–10%, smoothing rough keratosis pilaris and xerosis without acid stinging.

Addresses Skin Concerns
Rough keratin plugsSevere dry scalingThickened skin plaques
Recognized INCI Names on Packaging Labels
UreaHydroxyethyl Urea
Compatible Synergies
  • ✓Lactic Acid
  • ✓Ceramides
  • ✓Squalane
Separate or Alternate
  • ⚠️Open exuding dermatitis