Centella Asiatica & Madecassoside
Niacinamide (Vitamin B3)
How to Layer These Actives in Your Routine
Centella Asiatica & Madecassoside
Apply first to clean, dry skin. Operates at pH 5–6.5.
Allows cutaneous acid mantle to equilibrate before the next step.
Niacinamide (Vitamin B3)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Centella Asiatica & Madecassoside and Niacinamide (Vitamin B3) operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Centella Asiatica & Madecassoside (pH 5–6.5, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Niacinamide (Vitamin B3).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Centella Asiatica & Madecassoside ✓Broad-Spectrum SPF 50+ | •Centella Asiatica & Madecassoside •Niacinamide (Vitamin B3) •Barrier Cream | •Centella Asiatica & Madecassoside •Niacinamide (Vitamin B3) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Centella Asiatica & Madecassoside is classified as PERMITTED during pregnancy, while Niacinamide (Vitamin B3) is classified as PERMITTED under clinical guidelines. Always cross-reference with your physician if expecting.