← Back to Ingredients Directory
Barrier Cofactors & BrightenersRecommended: AM/PM Slot
Niacinamide (Vitamin B3)
Clinical Overview
A water-soluble B3 amide essential for cellular energy metabolism (NAD+/NADP+), sebum regulation, and ceramide synthesis.
Epidermal & Cutaneous Mechanism
Inhibits melanosome transfer from melanocyte dendrites into surrounding keratinocytes by 35%–68%, reduces sebaceous lipogenesis, and boosts filaggrin.
Addresses Skin Concerns
Pore enlargement & oilinessPost-inflammatory dark spotsBarrier compromise
Recognized INCI Names on Packaging Labels
NiacinamideNicotinamide
Compatible Synergies
- ✓Retinoids (enhances tolerance)
- ✓Vitamin C (compatible in modern formulas)
- ✓Zinc PCA
- ✓Hyaluronic Acid
Separate or Alternate
- No significant contraindications documented.