Niacinamide (Vitamin B3)
Panthenol (Provitamin B5)
How to Layer These Actives in Your Routine
Niacinamide (Vitamin B3)
Apply first to clean, dry skin. Operates at pH 5–6.5.
Allows cutaneous acid mantle to equilibrate before the next step.
Panthenol (Provitamin B5)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Niacinamide (Vitamin B3) and Panthenol (Provitamin B5) operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Niacinamide (Vitamin B3) (pH 5–6.5, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Panthenol (Provitamin B5).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Niacinamide (Vitamin B3) ✓Broad-Spectrum SPF 50+ | •Niacinamide (Vitamin B3) •Panthenol (Provitamin B5) •Barrier Cream | •Niacinamide (Vitamin B3) •Panthenol (Provitamin B5) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Niacinamide (Vitamin B3) is classified as PERMITTED during pregnancy, while Panthenol (Provitamin B5) is classified as PERMITTED under clinical guidelines. Always cross-reference with your physician if expecting.