Niacinamide (Vitamin B3)
Tretinoin (All-Trans Retinoic Acid)
How to Layer These Actives in Your Routine
Niacinamide (Vitamin B3)
Apply first to clean, dry skin. Operates at pH 5–6.5.
Allows cutaneous acid mantle to equilibrate before the next step.
Tretinoin (All-Trans Retinoic Acid)
Layer over the initial active. Operates at pH 5–6.5.
Biochemical Mechanism & Pharmacology
Niacinamide (Vitamin B3) and Tretinoin (All-Trans Retinoic Acid) operate via distinct physiological mechanisms without reactive cross-oxidation or competing receptor antagonisms. They can be safely integrated into the same routine when sequenced properly from thinnest to thickest consistency.
Apply Niacinamide (Vitamin B3) (pH 5–6.5, Viscosity Tier 2) first. Wait 1–2 minutes for absorption, then follow with Tretinoin (All-Trans Retinoic Acid).
Recommended 7-Day Routine Blueprint
| Morning (AM) Routine | Evening (Night A) | Evening (Night B) |
|---|---|---|
✓Gentle Cleanser ✓Niacinamide (Vitamin B3) ✓Broad-Spectrum SPF 50+ | •Niacinamide (Vitamin B3) •Tretinoin (All-Trans Retinoic Acid) •Barrier Cream | •Niacinamide (Vitamin B3) •Tretinoin (All-Trans Retinoic Acid) •Barrier Cream |
Obstetric & Pregnancy Safety Summary
View Full Pregnancy Directory →Niacinamide (Vitamin B3) is classified as PERMITTED during pregnancy, while Tretinoin (All-Trans Retinoic Acid) is classified as DEFER IN PREGNANCY under clinical guidelines. Always cross-reference with your physician if expecting.