Separate routines: alternate evenings
Pharmacological Mechanism
Both ingredients increase epidermal cell transit time and exfoliation rates through independent pathways. Layering them simultaneously elevates transepidermal water loss (TEWL) and drastically increases the likelihood of irritant contact dermatitis.
Miko Routine Guidance
Use on alternate nights, or use AHA/BHA in the morning and your retinoid in the evening.
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