Myth debunked: compatible to use together
The Historical Myth Explained
Myth: 'Vitamin C and Niacinamide cancel each other out or cause severe flushing.' Fact: Outdated 1960s laboratory heating experiments do not apply to modern ambient formulations.
Pharmacological Mechanism
The persistent belief that niacinamide and ascorbic acid cancel each other out stems from 1960s laboratory studies conducted at extreme temperatures (>120°C) and highly non-physiological acidities. Modern clinical formulations at room temperature do not form irreversible complexes or cause flushing in normal usage.
Miko Routine Guidance
Layer either order or use in the same AM/PM slot. No wait time is strictly required.
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